Official Title: “Prospective Comparison of Ampicillin / Amoxicillin Versus Ceftriaxone for the Treatment of Salmonella Infections in AIDS Patients”

To compare the effectiveness of standard treatment with parenteral ampicillin and oral amoxicillin compared to initial daily therapy with ceftriaxone followed by 3 times weekly suppressive treatment for salmonella infections in AIDS patients.

Study Type: Interventional

Study Design: Treatment, Dose Comparison

Intervention(s) in this Clinical Trial

• Drug: Ceftriaxone sodium
• Drug: Ampicillin sodium
• Drug: Amoxicillin trihydrate

Exclusion Criteria

Co-existing Condition:

Patients with the following are excluded:

• Type I hypersensitivity to beta-lactam antibiotics.
• Not expected to survive 12 weeks.
• In a coma or with other central nervous system (CNS) impairment.

Patients with the following are excluded:

• Type I hypersensitivity to beta-lactam antibiotics.
• Not expected to survive 12 weeks.
• In a coma or with other central nervous system (CNS) impairment.

Prior Medication:

Excluded within 48 hours of study entry:

• Treatment with an antibiotic active in vitro against Salmonella.
• HIV infection, AIDS, or AIDS related complex (ARC).
• Salmonella bacteremia or positive stool culture in patient with 3 or more stools per day.

Gender Eligibility for this Clinical Trial: Both

Minimum Age for this Clinical Trial: 18 Years

Maximum Age for this Clinical Trial: N/A

Are Healthy Volunteers Accepted for this Clinical Trial?: No

Lead Sponsor: University of Southern California

Information obtained from ClinicalTrials.gov on July 02, 2009

Link to the current ClinicalTrials.gov record. http://clinicaltrials.gov/show/NCT00002052

Study ID Number: 019A

ClinicalTrials.gov Identifier: NCT00002052

Health Authority: United States: Food and Drug Administration