Official Title: “Effects of Pretreatment With Ibuprofen in Post- ECT Headache”

The purpose of the study is to determine wether ibuprofen reduce post-ECT headache or reduce its severity.

Study Type: Interventional

Study Design: Treatment, Randomized, Double-Blind, Placebo Control, Crossover Assignment, Safety/Efficacy Study

Study Primary Completion Date: December 2009

The aim of the study is to compare the severity of headache between patients who are receiving ibuprofen prior to ECT treatment with patients receiving placebo prior to ECT treatment. Patients will be randomly assigned to receive either 600 mg ibuprofen 90 min prior to treatment or placebo orally, blinded to patient, physician and treatment team. Patients will be asked about their headache with a visual analogue scale (VAS) 2 hours prior to and within 2 hours after treatment, 2-month, 6- month and

1 year follow-up [5].

Intervention(s) in this Clinical Trial

• Drug: Ibuprofen

Primary Measures

• Score on depression rating scale prior to and after ECT treatment
• score on headache prior to and after ECT treatment

Secondary Measures

• ECT parameters

Inclusion Criteria:

• Patients receiving ECT

Exclusion Criteria:

• Pregnancy, contraindications to ibuprofen

Gender Eligibility for this Clinical Trial: Both

Minimum Age for this Clinical Trial: 18 Years

Maximum Age for this Clinical Trial: N/A

Are Healthy Volunteers Accepted for this Clinical Trial?: No

Lead Sponsor: Norwegian University of Science and Technology

Overall Clinical Trial Officials and Contacts

Olav Morten Linaker, MD PhD Principal Investigator Norwegian University of Science and Technology  

Overall Contact: Lindy Jarosch-von Schweder, MD 47 73864533 lindy.jarosch@ntnu.no

Information obtained from ClinicalTrials.gov on July 02, 2009

Link to the current ClinicalTrials.gov record. http://clinicaltrials.gov/show/NCT00258791

Study ID Number: LVS-2005

ClinicalTrials.gov Identifier: NCT00258791

Health Authority: Norway: Norwegian Social Science Data Services