Official Title: “Effects of Pretreatment With Ibuprofen in Post- ECT Headache”

The purpose of the study is to determine wether ibuprofen reduce post-ECT headache or reduce its severity.

Study Type: Interventional

Study Design: Treatment, Randomized, Double-Blind, Placebo Control, Crossover Assignment, Safety/Efficacy Study

The aim of the study is to compare the severity of headache between patients who are receiving ibuprofen prior to ECT treatment with patients receiving placebo prior to ECT treatment.

Patients will be randomly assigned to receive either 600 mg ibuprofen 90 min prior to treatment or placebo orally, blinded to patient, physician and treatment team.

Patients will be asked about their headache with a visual analogue scale (VAS) 2 hours prior to and within 2 hours after treatment, 2-month, 6- month and 1 year follow-up [5].

Primary:

• Score on depression rating scale prior to and after ECT treatment
• score on headache prior to and after ECT treatment

Secondary:

• ECT parameters

Inclusion Criteria:

• Patients receiving ECT

Exclusion Criteria:

• Pregnancy, contraindications to ibuprofen

Lead Sponsor: Norwegian University of Science and Technology

Østmarka Psychiatric Department, St. OLavs Hospital, University Hospital of Trondheim

Trondheim   Norway

Overall Clinical Trial Officials and Contacts

Olav Morten Linaker, MD PhD Principal Investigator Norwegian University of Science and Technology  

Overall Contact: Lindy Jarosch-von Schweder, MD 47 73864533 lindy.jarosch@ntnu.no

Information obtained from ClinicalTrials.gov on July 18, 2008

Link to the current ClinicalTrials.gov record. http://clinicaltrials.gov/show/NCT00258791

Study ID Number: LVS-2005

ClinicalTrials.gov Identifier: NCT00258791

Health Authority: Norway: Norwegian Social Science Data Services