Official Title: “Phase 1 Study of Hydroxychloroquine in Cystic Fibrosis”

Study levels of inflammatory mediators in induced sputum of patients with cystic fibrosis before and after a 4 week course of oral hydroxychloroquine.

Study Type: Interventional

Study Design: Treatment, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment

Study Primary Completion Date: December 2007

Open label study of effect of hydroxychloroquine on inflammation, bacterial burden and exhaled breath condensate pH in patients with cystic fibrosis.

Patients with cystic fibrosis, 16 years or older and with pulmonary function tests with an FEV1 greater than 40% predicted will be eligible for enrollment. Enrolled subjects will undergo collection of exhaled breath condensate and sputum induction and collection following nebulized hypertonic saline, before and following a 4 week course of oral hydroxychloroquine at 200 mg a day. Inflammatory mediators, neutrophil counts, and bacterial density in sputum and exhaled breath condensate pH will be measure at entry and at the end of 4 weeks of oral drug. There will be no placebo group.

Intervention(s) in this Clinical Trial

• Drug: hydroxychloroquine

Primary Measures

• Change in inflammatory mediators and exhaled breath condensate pH following 4 week administration of drug.
  • Time Frame: 28 days
    Safety Issue?: No

Inclusion Criteria:

• 1. Male or female between 16 years and 65 years of age.
• 2. Confirmed diagnosis of CF based on the following criteria:
• i. positive sweat chloride 60 mEq/liter (by pilocarpine iontophoresis) and/or ii. a genotype with two identifiable mutations consistent with CF, and iii. accompanied by one or more clinical features consistent with the CF phenotype
• 3. FEV1 50% predicted value (subjects 16- <18 years of age) or 40% predicted value (subjects 18 years of age)
• 4. Clinically stable with no evidence of acute upper or lower respiratory tract infection or current pulmonary exacerbation within the 14 days prior to Visit 1 (Day 0)
• 5. Ability to reproducibly perform spirometry and peak flow measurements
• 6. Ability to understand and sign a written informed consent or assent and comply with the requirements of the study

Exclusion Criteria:

• 1. Use of an investigational agent within the 4-week period prior to Visit 1
• 2. Chronic daily use of ibuprofen or other NSAIDs, or systemic corticosteroids, or any oral diabetic or hypoglycemic agent within the 4 weeks prior to Visit 1 or acute usage within 72 hours prior to Visit 1
• 3. History of hypersensitivity to beta-agonists
• 4. History of hypersensitivity to hydroxychloroquine or chloroquine
• 5. Oxygen saturation < 92% on room air at Visit 1
• 6. Pregnant, breastfeeding, or unwilling to practice birth control during participation in the study
• 7. History of hemoptysis 30 cc per episode during the 30 days prior to Visit 1
• 8. Significant history of hepatic, cardiovascular, renal, neurological, hematologic, or peptic ulcer disease

Gender Eligibility for this Clinical Trial: Both

Minimum Age for this Clinical Trial: 16 Years

Maximum Age for this Clinical Trial: N/A

Are Healthy Volunteers Accepted for this Clinical Trial?: No

Lead Sponsor: Vanderbilt University

Overall Clinical Trial Officials and Contacts

Bonnie S Slovis, MD Principal Investigator Vanderbilt University  

Information obtained from ClinicalTrials.gov on July 02, 2009

Link to the current ClinicalTrials.gov record. http://clinicaltrials.gov/show/NCT00311883

Study ID Number: 060051

ClinicalTrials.gov Identifier: NCT00311883

Health Authority: United States: Institutional Review Board