To compare the short-term mean 24-hour intraocular pressure (IOP) control, 24-hour blood pressure (BP) effect and safety of Latanoprost/Timolol fixed combination given once in the evening with placebo once in the morning versus timolol maleate 0.5% given twice daily in patients with ocular hypertension (OHT), and primary open-angle glaucoma (POAG)...
Date First Received: May 26, 2006
Last Updated: May 7, 2008
Verified by: Aristotle University Of Thessaloniki, May 2008
Clinical Trial Phase: Phase 4 | Start Date: April 2006
Overall Status: Completed
Estimated Enrollment: 30
Brief Summary
Condition Keyword(s):
To compare the short-term mean 24-hour intraocular pressure (IOP) control, 24-hour blood pressure (BP) effect and safety of Latanoprost/Timolol fixed combination given once in the evening with placebo once in the morning versus timolol maleate 0.5% given twice daily in patients with ocular hypertension (OHT), and primary open-angle glaucoma (POAG).
Study Type: Interventional
Study Design: Treatment, Randomized, Double-Blind, Active Control, Crossover Assignment
Study Primary Completion Date: April 2007
Intervention(s) in this Clinical Trial
- Drug: timolol maleate 0.5%
- Drug: latanoprost/timolol fixed combination
- Drug: placebo (artificial tears)
Criteria for Participation in this Clinical Trial
Inclusion Criteria:
- POAG
- OHT
Exclusion Criteria:
- Advanced glaucoma
- Arterial Hypertension
Gender Eligibility for this Clinical Trial: Both
Minimum Age for this Clinical Trial: 29 Years
Maximum Age for this Clinical Trial: 80 Years
Are Healthy Volunteers Accepted for this Clinical Trial?: No
Clinical Trial Sponsor Information
Lead Sponsor: Aristotle University Of Thessaloniki
Overall Clinical Trial Officials and Contacts
AGP Konstas, MD, PhD Principal Investigator Glaucoma Unit, A University Dept of Ophthalmology, AHEPA Hospital
Additional Information
Information obtained from ClinicalTrials.gov on September 05, 2008
Link to the current ClinicalTrials.gov record. http://clinicaltrials.gov/show/NCT00330577
Study ID Number: A594
ClinicalTrials.gov Identifier: NCT00330577
Health Authority: Greece: National Organization of Medicines
Clinical Trials Authorship and Review
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