Official Title: “Bioavailabilty of Bimatoprost Ophthalmic Solution in Human Aqueous.”

The purpose of this study is to assay human aqueous for bimatoprost and the presence of any metabolites, especially prostaglandin analogs. Hypothesis:Bimatoprost is not metabolized to a prostaglandin F-2-alpha analog in human eyes - Bimatoprost levels in human aqueous peak approximately three hours post dosing

Study Type: Interventional

Study Design: Treatment, Randomized, Double-Blind, Active Control, Parallel Assignment, Bio-availability Study

The purpose of this study is to assay human aqueous for bimatoprost and the presence of any metabolites, especially prostaglandin analogs

Intervention(s) in this Clinical Trial

• Drug: Bimatoprost 0.03%

Primary Measures

• Bimatoprost free acid in human aqueous

Inclusion Criteria:

• All subjects must:
• 1. Be willing and able to provide written Informed Consent.
• 2. Be able and willing to follow instructions and likely to complete the entire course of the study.
• 3. Be male or female of any race at least 18 years of age.
• 4. Have visually significant cataract for which they have elected to undergo cataract surgery..

Exclusion Criteria:

• No subject may:
• 1. Have any contraindication to use of a prostaglandin analog or prostamide derivative.
• 3. Have any active ocular disease other than glaucoma or ocular hypertension that would interfere with study parameters (such as: uveitis, ocular infection, or severe dry eye). Patients with mild chronic blepharitis, age-related macular degeneration, background diabetic retinopathy may be enrolled at the discretion of the investigator.
• 4. Have laser or any other intraocular surgery within the past three months.
• 5. Require use of ocular medications (including glaucoma medications), except intermittent use of artificial tears. Patients may not have a history of ever having used a prostaglandin analog topically.
• 6. Have known allergy or sensitivity to the study medications or their components 7. Have corneal abnormalities that would interfere with the ability to obtain an adequate sample safely or have a shallow anterior which would make obtaining an aqueous sample difficult at the time of surgery in the opinion of the investigator.
• 8. Be concurrently enrolled in an investigational drug or device study or participation within the last 30 days in any investigational drug or device study.
• 9. Be pregnant, nursing, planning a pregnancy, or be of childbearing potential and not using a reliable form of contraception (a woman is considered of childbearing potential unless she is postmenopausal, has had a uterus and/or both ovaries removed, or has had a bilateral tubal ligation).
• 10. Have a situation or condition that in the investigator's opinion may put the subject at significant risk, may confound the study results, or may interfere significantly with participation in the study.

Gender Eligibility for this Clinical Trial: Both

Minimum Age for this Clinical Trial: 18 Years

Maximum Age for this Clinical Trial: N/A

Are Healthy Volunteers Accepted for this Clinical Trial?: No

Lead Sponsor: Indiana University School of Medicine

Overall Clinical Trial Officials and Contacts

Louis B Cantor, MD Principal Investigator IUPUI/Clarian  

Information obtained from ClinicalTrials.gov on September 05, 2008

Link to the current ClinicalTrials.gov record. http://clinicaltrials.gov/show/NCT00355446

Study ID Number: 0106-24

ClinicalTrials.gov Identifier: NCT00355446

Health Authority: United States: Food and Drug Administration