Official Title: “Application of Sildenafil in Patients With Documented Coronary Vasospasm to Explore the Pathophysiology of Coronary Vasospasm and the Therapeutic Effect of Sildenafil in Patients Suffering From Coronary Vasospasm”

This will be a prospective, phase IIIb, double-blind and randomized trial testing the effect of single dose sildenafil application in patients with coronary vasospasm compared to placebo application.

The target variable to be tested is the degree of coronary vasoconstriction in response to intracoronary ACh application (in addition to clinical chest pain) which will be imaged by coronary angiography and measured using quantitative coronary angiography software.

Main objective: Has sildenafil the potency to inhibit the induction of coronary vasospasm by intracoronary ACh-application in patients with proven coronary artery spasm?

Secondary objective: Which degree of coronary vasospasm inhibition can be achieved with sildenafil?

Study Type: Interventional

Study Design: Treatment, Randomized, Double Blind (Subject, Caregiver, Investigator), Placebo Control, Parallel Assignment, Efficacy Study

Study Primary Completion Date: December 2009

Coronary artery spasm is an abrupt severe vasoconstrictor response which may occur spontaneously in normal and diseased coronary arteries. It may result in myocardial ischemia and may be provoked by various stimuli such as acetylcholine (ACh). Coronary vasospasm is involved in the pathogenesis of Prinzmetal's angina, acute myocardial infarction or sudden cardiac death due to ventricular arrythmias and chest pain symptoms associated with viral myocarditis.

The precise cellular and molecular mechanisms of coronary vasospasm have not yet been elucidated. The most often suggested but competing explanations for this disease are coronary endothelial dysfunction secondary to impaired nitric oxide production versus coronary smooth muscle cell hyperreactivity with or without additional endothelial dysfunction. As the precise cellular mechanism is currently unknown a large group of people can currently not be treated appropriately despite the use of nitrates and calcium antagonists.

Sildenafil is a phosphodiesterase(PDE)-5 inhibitor approved for the treatment of both erectile dysfunction and pulmonary hypertension. PDE-5 has been shown to be also present and play an important vasomotor role in the coronary vessel wall. Application of the inhibitor sildenafil has been shown to increase the resting coronary artery diameter. Furthermore, atherosclerotic coronary artery segments which vasoconstrict following intracoronary ACh-application vasodilate following the application of sildenafil when ACh-testing is repeated. Other studies are also suggesting an improved endothelial function after sildenafil application for both the coronary and the peripheral vasculature.

Taken together, sildenafil is expected to have a positive effect on coronary vasomotility.

Whether sildenafil can totally prevent the occurrence of coronary vasospasm or at least decrease the severity of vasospasm has not been studied so far. Thus, the aim of this study is to analyse the possible anti-spastic effects of sildenafil in patients suffering from coronary vasospasm.

Intervention(s) in this Clinical Trial

• Drug: single dose Sildenafil
  • Application of a single dose Sildenafil
• Drug: Single dose placebo
  • Application of a single dose placebo

Arms, Groups and Cohorts in this Clinical Trial

• Active Comparator: A
  • Sildenafil arm
• Placebo Comparator: B
  • Placebo arm

Primary Measures

• Incidence of coronary vasospasm in spite of medical treatment
  • Time Frame: After inclusion of last patient
    Safety Issue?: No

Inclusion Criteria:

• age ≥ 50y
• Framingham risk score < 10%
• no contraindication to sildenafil application
• clinical history of atypical angina pectoris
• exclusion of significant coronary artery disease (stenosis ≥ 50%) by coronary angiography
• documented coronary spasm by ACh-testing in at least one coronary artery segment
• written informed consent

Exclusion Criteria:

• existing contraindication to sildenafil application
• significant coronary artery disease (≥ 50%)
• valvular, inflammatory, dilative or other cardiomyopathies
• congestive heart failure (left ventricular ejection fraction < 60%) of any reason
• need for therapeutic treatment with nitrates or intake of any nitrates in the last 24h before coronary angiography
• participation in another clinical trial at the moment or in the last 30 days
• hypotonic blood pressure (<90/50mmHg)
• hepatic insufficiency (> Child-Pugh-classification A)
• renal insufficiency with a GFR < 60ml/min- pregnancy or lactation
• not able to consent

Gender Eligibility for this Clinical Trial: Both

Minimum Age for this Clinical Trial: 50 Years

Maximum Age for this Clinical Trial: N/A

Are Healthy Volunteers Accepted for this Clinical Trial?: No

Lead Sponsor: Dr. Margarete Fischer-Bosch-Institut für Klinische Pharmakologie (IKP) am Robert-Bosch-Krankenhaus (RBK)

Overall Clinical Trial Officials and Contacts

Udo Sechtem, MD Study Director Robert-Bosch-Krankenhaus Stuttgart  

Information obtained from ClinicalTrials.gov on August 29, 2008

Link to the current ClinicalTrials.gov record. http://clinicaltrials.gov/show/NCT00454714

Study ID Number: RBK091

ClinicalTrials.gov Identifier: NCT00454714

Health Authority: Germany: Federal Institute for Drugs and Medical Devices