Official Title: “Preoperative Treatment With NSAID in Colorectal Cancer Patients in Relationship to Tumor Host Reactions”

The study is designed to evaluate effects of NSAIDs on immune activity inside and close to tumor tissue in patients with colorectal cancer.

Study Type: Interventional

Study Design: Treatment, Randomized, Open Label, Active Control, Parallel Assignment, Efficacy Study

Study and control patients are randomized to receive preoperative treatment with indomethacin or celecoxib compared to sham treatment.Tumor biopsies are taken at operation and used for analyses of tumor immunity and gene expression.

Intervention(s) in this Clinical Trial

• Drug: Indomethacin, celecoxib, esomeprazole

Primary Measures

• Immune reactivity
  • Time Frame: Acute evaluations
    

Inclusion Criteria:

• Colon carcinoma scheduled for curative operation

Exclusion Criteria:

• Diabetes, steroid medication, liver and kidney impairment

Gender Eligibility for this Clinical Trial: Both

Minimum Age for this Clinical Trial: 40 Years

Maximum Age for this Clinical Trial: 80 Years

Are Healthy Volunteers Accepted for this Clinical Trial?: No

Lead Sponsor: Göteborg University

Overall Clinical Trial Officials and Contacts

Kent Lundholm, MD, prof Principal Investigator Göteborg University  

Information obtained from ClinicalTrials.gov on August 29, 2008

Link to the current ClinicalTrials.gov record. http://clinicaltrials.gov/show/NCT00473980

Study ID Number: kl4501122

ClinicalTrials.gov Identifier: NCT00473980

Health Authority: Sweden: The National Board of Health and Welfare

Göteborg University