Recently we have shown that melatonin secretion is impaired in rats with metabolic syndrome. We have also demonstrated that exogenic melatonin supplementation can improve blood pressure profile in nondipper patients. The aim of this study is to find whether there is a difference between melatonin secretion in hypertensive kidney recipients versus "normal" hypertensive patients. Secondly, to ask...
Date First Received: July 8, 2007
Last Updated: May 5, 2008
Verified by: Sheba Medical Center, April 2008
Clinical Trial Phase: N/A | Start Date: September 2007
Overall Status: Recruiting
Estimated Enrollment: 60
Brief Summary
Condition Keyword(s):
Recently we have shown that melatonin secretion is impaired in rats with metabolic syndrome.
We have also demonstrated that exogenic melatonin supplementation can improve blood pressure profile in nondipper patients.
The aim of this study is to find whether there is a difference between melatonin secretion in hypertensive kidney recipients versus "normal" hypertensive patients. Secondly, to ask if there is any correlation between melatonin secretion and adiponectin levels.
Study Type: Observational
Study Design: Case Control, Prospective
Arms, Groups and Cohorts in this Clinical Trial
- : 1
- kidney transplant with hypertension
- : 2
- hypertensive patients with native kidneys
- : 3
- healthy controls
Criteria for Participation in this Clinical Trial
Inclusion Criteria:
- hypertension
- kidney transplantation ( group 1)
- good renal function
Exclusion Criteria:
- diabetes mellitus
- cancer
- renal failure
Gender Eligibility for this Clinical Trial: Both
Minimum Age for this Clinical Trial: 18 Years
Maximum Age for this Clinical Trial: 70 Years
Are Healthy Volunteers Accepted for this Clinical Trial?: Accepts Healthy Volunteers
Clinical Trial Sponsor Information
Lead Sponsor: Sheba Medical Center
Overall Clinical Trial Officials and Contacts
Avshalom Leibowitz, MD Principal Investigator Unaffiliated.
Overall Contact: Avshalom Leibowitz, MD 972-3-530-2834 leiboa@gmail.com
Additional Information
Information obtained from ClinicalTrials.gov on October 15, 2008
Link to the current ClinicalTrials.gov record. http://clinicaltrials.gov/show/NCT00498576
Study ID Number: SHEBA-07-4730-AL-CTIL
ClinicalTrials.gov Identifier: NCT00498576
Health Authority: Israel: Israeli Health Ministry Pharmaceutical Administration
Clinical Trials Authorship and Review
Clinical Trials content is provided directly by the U.S. National Institutes of Health via ClinicalTrials.gov and is not reviewed separately by ClinicalTrialsFeeds.org. Every page of specific clinical trials information contains a unique identifier which can be used to find further details directly from the National Institutes of Health.
