Nonsteroidal antiinflammatory drugs such as diclofenac or naproxen may interfere with the inhibition of platelet aggregation by aspirin, because they all interact with the platelet cyclooxygenase.This may be of great clinical importance because of an increased cardiovascular event rate (myocardial infarction, stroke). The present randomized, controlled study analyses in vitro platelet aggregation...
Date First Received: September 26, 2007
Last Updated: September 27, 2007
Verified by: Kantonsspital Graubünden, September 2007
Clinical Trial Phase: N/A | Start Date: August 2006
Overall Status: Completed
Estimated Enrollment: 11
Brief Summary
Condition Keyword(s):
Nonsteroidal antiinflammatory drugs such as diclofenac or naproxen may interfere with the inhibition of platelet aggregation by aspirin, because they all interact with the platelet cyclooxygenase.This may be of great clinical importance because of an increased cardiovascular event rate (myocardial infarction, stroke). The present randomized, controlled study analyses in vitro platelet aggregation under a combined treatment of healthy volunteers with aspirin and either acetaminophen, diclofenac, naproxen, or placebo.
Study Type: Interventional
Study Design: Treatment, Randomized, Single Blind (Subject), Placebo Control, Parallel Assignment, Efficacy Study
Detailed Clinical Trial Description
An in vivo study on healthy volunteers with combinations of well established drugs
Outcome Measures for this Clinical Trial
Primary:
- platelet aggregation 5 days
Criteria for Participation in this Clinical Trial
Inclusion Criteria:
- Healthy volunteers
Exclusion Criteria:
- Administration of drugs affecting platelets
- History of bleeding
- Gastrointestinal disorders
- Hypersensitivity to aspirin and/or NSAID
- Pregnancy and breast feeding
Clinical Trials Locations, Contact Details, and Sponsors
Lead Sponsor: Kantonsspital Graubünden
Kantonsspital Graubünden, Department of Internal Medicine
Chur CH 7000 Switzerland
Overall Clinical Trial Officials and Contacts
Walter H Reinhart, MD Professor Principal Investigator Department of Internal Medicine, Kantonsspital Graubunden CH7000 Chur Switzerland
Additional Information
Information obtained from ClinicalTrials.gov on July 18, 2008
Link to the current ClinicalTrials.gov record. http://clinicaltrials.gov/show/NCT00536068
Study ID Number: KGWR0206
ClinicalTrials.gov Identifier: NCT00536068
Health Authority: Switzerland: Swissmedic
Clinical Trials Authorship and Review
Clinical Trials content is provided directly by the U.S. National Institutes of Health via ClinicalTrials.gov and is not reviewed separately by ClinicalTrialsFeeds.org. Every page of specific clinical trials information contains a unique identifier which can be used to find further details directly from the National Institutes of Health.
