The investigators hypothesized simvastatin and pravastatin may have differential metabolic effects in hypercholesterolemic patients...
Date First Received: October 18, 2007
Last Updated: August 28, 2008
Verified by: Gachon University Gil Medical Center, August 2008
Clinical Trial Phase: N/A | Start Date: January 2004
Overall Status: Completed
Brief Summary
Condition Keyword(s):
Intervention(s):
The investigators hypothesized simvastatin and pravastatin may have differential metabolic effects in hypercholesterolemic patients.
Study Type: Observational
Study Design: Case Control, Prospective
Intervention(s) in this Clinical Trial
- Drug: statins (simvastatin, pravastatin)
Outcome Measures for this Clinical Trial
Primary Measures
- Simvastatin and pravastatin may have differential metabolic effects in hypercholesterolemic patients.
Criteria for Participation in this Clinical Trial
Inclusion Criteria:
- Low-density lipoprotein cholesterol levels > 130
Exclusion Criteria:
- Overt liver disease,
- Chronic renal failure
- Hypothyroidism
- Myopathy
- Uncontrolled diabetes
- Severe hypertension
Gender Eligibility for this Clinical Trial: Both
Minimum Age for this Clinical Trial: 25 Years
Maximum Age for this Clinical Trial: 75 Years
Clinical Trial Sponsor Information
Lead Sponsor: Gachon University Gil Medical Center
Overall Clinical Trial Officials and Contacts
Kwang K Koh, MD,PhD Principal Investigator Gachon University Gil Medical Center
Related Publications
Citations Reporting Results
Yada T, Nakata M, Shiraishi T, Kakei M. Inhibition by simvastatin, but not pravastatin, of glucose-induced cytosolic Ca2+ signalling and insulin secretion due to blockade of L-type Ca2+ channels in rat islet beta-cells. Br J Pharmacol. 1999 Mar;126(5):1205-13.
Additional Information
Information obtained from ClinicalTrials.gov on October 10, 2008
Link to the current ClinicalTrials.gov record. http://clinicaltrials.gov/show/NCT00546559
Study ID Number: GMC-200406
ClinicalTrials.gov Identifier: NCT00546559
Health Authority: South Korea: Institutional Review Board
Clinical Trials Authorship and Review
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