Official Title: “Effect of Gatifloxacin 0.3% and Moxifloxacin 0.5% on Epithelial Wound Healing After Photorefractive Keratectomy”

The prescribed antibiotic for prophylaxis of infection following PRK should be effective at eradicating a potential infection. In addition, the antibiotic should have a rapid onset of action, effectively penetrate the target tissue, and be safe and not toxic to any layer of the healing cornea, especially the epithelium. Several studies have investigated the toxicity of the fourth generation fluoroquinolones on the corneal epithelium and studies have demonstrated that gatifloxacin is less deleterious to the healing cornea than moxifloxacin.

Most of these studies, however, have been conducted in animals. This was a retrospective chart review.

Study Type: Observational

Study Design: Case Control, Retrospective

Prior generation fluoroquinolones predominantly either inhibit topoisomerase II (DNA Gyrase) or topoisomerase IV and therefore only require one genetic mutation for bacteria to develop resistance. Fourth-generation fluoroquinolones are equally effective against topoisomerase II and IV, which significantly expands their spectrum of action against gram-positive agents and atypical mycobacteria and Nocardia . This duality of action of the fourth generation fluoroquinolones requires that for bacteria to become resistant to these agents, the bacteria must undergo two genetic mutations resulting in a significantly decreased chance of an organism developing resistance.Minimum inhibitory concentrations determined in vitro suggest that fourth-generation fluoroquinolones are more effective than second- and third-generation fluoroquinolones against gram-positive bacteria including Staphylococcal species found in endophthalmitis and bacterial keratitis cultures. The increased efficacy of fourth-generation fluoroquinolones make these antibiotics important agents to evaluate for prophylaxis against post-PRK infections. This was a retrospective chart review.

Intervention(s) in this Clinical Trial

• Drug: gatifloxacin and moxifloxacin
  • Comparison of wound healing between drugs

Arms, Groups and Cohorts in this Clinical Trial

• : 1
  • Corneal epithelial wound healing with moxifloxacin
• : 2
  • Corneal epithelial wound healing with gatifloxacin

Primary Measures

• Wound Healing
  • Time Frame: Days after PRK
    Safety Issue?: No

Inclusion Criteria:

• Patients were eligible for inclusion if they were a healthy male or female 18 years of age or older and were candidates for bilateral PRK.
• Eligible patients had a best-corrected Early Treatment of Diabetic Retinopathy Study (ETDRS) visual acuity score equivalent to a Snellen score of 20/30 or better in each eye, had a stable prescription for 1 year, were willing to participate in the study, and were able to comprehend and sign the informed consent form.
• All subjects were instructed that if they decide not to participate they could withdraw from the study at any time.

Exclusion Criteria:

• Patients were excluded from the study if they had a history of refractive or other ocular surgery in either eye.
• Patients with any condition which could delay wound healing were not eligible to participate.
• They were excluded if they had poor tolerance to any component of the masked study fluoroquinolones, Acular® LS (Allergan) or Pred Forte® (Allergan).
• Patients were also excluded if they required the use of a systemic antibiotic during the study period, were involved in another investigational study or had participated in a study within 30 days prior to the start of this study.

Gender Eligibility for this Clinical Trial: Both

Minimum Age for this Clinical Trial: 18 Years

Maximum Age for this Clinical Trial: N/A

Are Healthy Volunteers Accepted for this Clinical Trial?: Accepts Healthy Volunteers

Lead Sponsor: Donnenfeld, Eric, M.D.

Overall Clinical Trial Officials and Contacts

Eric Donnenfeld, MD Principal Investigator OCLI  

Information obtained from ClinicalTrials.gov on August 28, 2008

Link to the current ClinicalTrials.gov record. http://clinicaltrials.gov/show/NCT00569881

Study ID Number: Donnenfeld2

ClinicalTrials.gov Identifier: NCT00569881

Health Authority: United States: None Needed