To determine the effects of chronic sertraline treatment on brachial artery flow-mediated dilation in patients with chronic heart failure and...
Date First Received: December 22, 2007
Last Updated: June 12, 2008
Verified by: Yale University, June 2008
Clinical Trial Phase: N/A | Start Date: January 2006
Overall Status: Recruiting
Estimated Enrollment: 20
Brief Summary
Official Title: “Effects of Chronic Sertraline Hydrochloride Administration on Vascular Endothelial and Autonomic Function in Patients With Chronic Heart Failure”
Condition Keyword(s):
Intervention(s):
To determine the effects of chronic sertraline treatment on brachial artery flow-mediated dilation in patients with chronic heart failure and depression
Study Type: Observational
Study Design: Cohort, Prospective
Study Primary Completion Date: December 2008
Intervention(s) in this Clinical Trial
- Drug: sertraline
- open label 25-50 mg daily as tolerated
Arms, Groups and Cohorts in this Clinical Trial
- : A
- Chronic heart failure patients with concomitant depression
Outcome Measures for this Clinical Trial
Primary Measures
- Brachial artery flow-mediated dilation
- Time Frame: 2 months
Safety Issue?: No
- Time Frame: 2 months
Criteria for Participation in this Clinical Trial
Inclusion Criteria:
- Chronic heart failure with LVEF<40%, age >21 years
- Depression requiring medical treatment with sertraline
Exclusion Criteria:
- Known intolerance of sertraline
Gender Eligibility for this Clinical Trial: Both
Minimum Age for this Clinical Trial: 21 Years
Maximum Age for this Clinical Trial: N/A
Are Healthy Volunteers Accepted for this Clinical Trial?: No
Clinical Trial Sponsor Information
Lead Sponsor: Yale University
Overall Clinical Trial Officials and Contacts
Stuart Katz, MD Principal Investigator Yale School of Medicine
Overall Contact: Stuart Katz, MD 203-785-7191 stuart.katz@yale.edu
Additional Information
Information obtained from ClinicalTrials.gov on October 10, 2008
Link to the current ClinicalTrials.gov record. http://clinicaltrials.gov/show/NCT00585455
Study ID Number: 0410027131
ClinicalTrials.gov Identifier: NCT00585455
Health Authority: United States: Institutional Review Board
Clinical Trials Authorship and Review
Clinical Trials content is provided directly by the U.S. National Institutes of Health via ClinicalTrials.gov and is not reviewed separately by ClinicalTrialsFeeds.org. Every page of specific clinical trials information contains a unique identifier which can be used to find further details directly from the National Institutes of Health.
