Official Title: “Single-Dose Fasting Bioequivalence Study of Fluoxetine Capsules (40 mg; Mylan) and Prozac Pulvules (40 mg; Dista) in Healthy Adult Volunteers”

The objective of this study is to investigate the bioequivalence of Mylan's fluoxetine hydrochloride 40 mg capsules to Dista's Prozac 40 mg pulvules following a single, oral 40 mg (1 x 40 mg) dose administration under fasting conditions.

Study Type: Interventional

Study Design: Allocation: Randomized, Endpoint Classification: Bio-equivalence Study, Intervention Model: Crossover Assignment, Masking: Open Label

Study Primary Completion Date: April 2006

Intervention(s) in this Clinical Trial

• Drug: Fluoxetine Capsules 40 mg
  • 40mg, single dose fasting
• Drug: Prozac Pulvules 40 mg
  • 40mg, single dose fasting

Arms, Groups and Cohorts in this Clinical Trial

• Experimental: 1
  • Fluoxetine Capsules 40 mg
• Active Comparator: 2
  • Prozac Pulvules 40 mg

Primary Measures

• Bioequivalence
  • Time Frame: within 30 days
    Safety Issue?: No

Inclusion Criteria:

• 1. Age: 18 years and older.
• 2. Sex: Male and/or non-pregnant, non-lactating female. a. Women of childbearing potential must have negative serum beta human chorionic gonadotropin (b-HCG) pregnancy tests performed within 21 days prior to the start of the study and on the evening prior to each dose administration. If dosing is scheduled on weekends, the HCG pregnancy test should be given within 48 hours prior to dosing of each study period. An additional serum (b-HCG) pregnancy test will be performed upon completion of the study. b. Women of childbearing potential must practice abstinence or be using an acceptable form of contraception throughout the duration of the study. No hormonal contraceptives or hormone replacement therapy are permitted in this study.
• Acceptable forms of contraception include the following: 1) intrauterine device in place for at least 3 months prior to the start of the study and remaining in place during the study period, or 2) barrier methods containing or used in conjunction with a spermicidal agent, or 3) surgical sterility (tubal ligation, oophorectomy or hysterectomy) or postmenopausal accompanied with a documented postmenopausal course of at least one year. c. Women will not be considered of childbearing potential if one of the following is reported and documented on the medical history: 1) postmenopausal with an absence of menses for at least one 2) bilateral oophorectomy with or without a hysterectomy and 3) total hysterectomy d. During the course of the study, from study screen until study exit, all men and women of childbearing potential must use a spermicide-containing barrier method of contraception in addition to their current contraceptive device. This requirement should be documented in the informed consent form.
• 3. Weight:At least 60 kg (132 lbs) for men and 48 kg (106 lbs) for women with all subjects having a Body Mass Index (BMI) less than or equal to 30 but greater than or equal to 19. (See Part II ADMINISTRATIVE ASPECTS OF BIOEQUIVALENCE PROTOCOLS).
• 4. All subjects should be judged normal and healthy during a pre-study medical evaluation (physical examination, laboratory evaluation, Hepatitis B and Hepatitis C tests, HIV test, 12-lead ECG, and urine drug screen including amphetamine, barbiturates, benzodiazepines, cannabinoid, cocaine, opiates, phencyclidine, and methadone) performed within 21 days of the initial dose of study medication.

Exclusion Criteria:

• 1. Institutionalized subjects will not be used.
• 2. Social Habits: a. Use of any tobacco products within one year prior to dosing. b.
• Ingestion of any alcoholic, caffeine- or xanthine-containing food or beverage within the 48 hours prior to the initial dose of study medication. c. Ingestion of any vitamins or herbal products within 7 days prior to the initial dose of the study medication. d. Any recent, significant change in dietary or exercise habits. e. A positive test for any drug included in the urine drug screen. f. History of drug and/or alcohol abuse.
• 3. Medications: a. Use of any prescription or over-the-counter (OTC) medications within the 14 days prior to the initial dose of study medication, especially any monoamine oxidase inhibitor (MAOI). b. Use of any hormonal contraceptives and hormone replacement therapy within 3 months prior to study medication dosing. c. Use of any medication known to alter hepatic enzyme activity within 35 days prior to the initial dose of study medication.
• 4. Diseases: a. History of any significant cardiovascular, hepatic, renal, pulmonary, hematologic, gastrointestinal, endocrine, immunologic, dermatologic, or neurologic disease. b. Acute illness at the time of either the pre-study medical evaluation or dosing. c. A positive HIV, Hepatitis B, or Hepatitis C test. d. History of seizures or any psychiatric disorders.
• 5. Abnormal and clinically significant laboratory test results: a. Clinically significant deviation from the Guide to Clinically Relevant Abnormalities (See Part II ADMINISTRATIVE ASPECTS OF BIOEQUIVALENCE PROTOCOLS). b. Abnormal and clinically relevant ECG tracing.
• 6. Donation or loss of a significant volume of blood or plasma (> 450 mL) within 28 days prior to the initial dose of study medication.
• 7. Subjects who have received an investigational drug within 30 days prior to the initial dose of study medication.
• 8. Allergy or hypersensitivity to fluoxetine, any of the inactive ingredients, or other related products.
• 9. History of difficulties in swallowing, or any gastrointestinal disease which could affect the drug absorption.
• 10. Consumption of grapefruit or grapefruit containing products within 7 days of drug administration.

Gender Eligibility for this Clinical Trial: Both

Minimum Age for this Clinical Trial: 18 Years

Maximum Age for this Clinical Trial: N/A

Are Healthy Volunteers Accepted for this Clinical Trial?: Accepts Healthy Volunteers

Lead Sponsor: Mylan Pharmaceuticals

Overall Clinical Trial Officials and Contacts

James D Carlson, Pharm. D. Principal Investigator PRACS Institute Ltd.  

Information obtained from ClinicalTrials.gov on September 01, 2010

Link to the current ClinicalTrials.gov record. http://clinicaltrials.gov/show/NCT00649636

Study ID Number: FLUO-0603

ClinicalTrials.gov Identifier: NCT00649636

Health Authority: United States: Institutional Review Board

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