Official Title: “Effect of Propranolol on Responses to Drug-Related Imagery Scripts”

This study evaluates the effect of propranolol on drug-related memories.

Study Type: Interventional

Study Design: Basic Science, Randomized, Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Placebo Control, Parallel Assignment, Efficacy Study

Study Primary Completion Date: June 2012

Intervention(s) in this Clinical Trial

• Drug: propranolol
  • 40 mg given as a single oral administration in an opaque capsule
• Drug: placebo
  • matching capsule containing no active medication

Arms, Groups and Cohorts in this Clinical Trial

• Experimental: 1
• Placebo Comparator: 2

Primary Measures

• drug craving
  • Time Frame: 1 hr
    Safety Issue?: No

Secondary Measures

• galvanic skin response
  • Time Frame: 1 hr
    Safety Issue?: No

Inclusion Criteria:

• cocaine use; enrolled in methadone maintenance therapy; age 18-55

Exclusion Criteria:

• allergy or hypersensitivity to propranolol; medical or psychiatric disorder that would contraindicate propranolol administration; pregnant or breast feeding; taking medications that would contraindicate propranolol administration

Gender Eligibility for this Clinical Trial: Both

Minimum Age for this Clinical Trial: 18 Years

Maximum Age for this Clinical Trial: 55 Years

Are Healthy Volunteers Accepted for this Clinical Trial?: No

Lead Sponsor: National Institute on Drug Abuse (NIDA)

Overall Clinical Trial Officials and Contacts

Overall Contact: Kenzie Preston, Ph.D. 443-740-2326 kpreston@intra.nida.nih.gov

Information obtained from ClinicalTrials.gov on October 10, 2008

Link to the current ClinicalTrials.gov record. http://clinicaltrials.gov/show/NCT00688805

Study ID Number: NIDAIRP433

ClinicalTrials.gov Identifier: NCT00688805

Health Authority: United States: Federal Government