Hormonal and Metabolic Consequences of Sleep Disorders in Young Obese Patients

Brief Summary

Official Title: “Hormonal and Metabolic Consequences of Sleep Disorders in Young Obese Patients”

There is a well-documented relationship between short sleep duration and high body mass index (BMI). The mechanism linking short sleep duration and weight gain is unknown. Current studies in healthy young volunteers have shown that experimental sleep restriction is associated with dysregulation of the neuroendocrine control of appetite and with alterations in glucose metabolism. The goal of our study is to determine the metabolic and hormonal modifications induced by chronic sleep curtailment in obese adolescents and young adults and to observe if short sleep is a negative prognostic factor in their weight evolution.

  • Study Type: Observational
  • Study Design: Observational Model: Cohort, Time Perspective: Cross-Sectional

Detailed Clinical Trial Description

The main purpose of the study is investigate whether the concentrations of 2 hormones that regulate appetite (leptin, ghrelin), cytokines (TNF-a, IL-6) and CRP are modified in obese adolescents and young adults who had sleep disorders in comparison to obese adolescents and young adults who sleep longer.

Arms, Groups and Cohorts in this Clinical Trial

  • 1
    • Obese adolescent and young adult with sleep disorder
  • 2
    • Obese adolescent and young adult without sleep disorder
  • 3
    • Lean adolescent and young adult with sleep disorder

Criteria for Participation in this Clinical Trial

Inclusion Criteria

  • 13-25 years old
  • BMI > 30 kg/m2 (If adolescents aged under 18 years: BMI equivalent to a BMI for age and sex to a BMI of 30, according to the Cole et al. obesity criteria).

Exclusion Criteria

  • Infection
  • Liver disease
  • Chronic inflammatory disease
  • Endocrine disease
  • Use of drugs that alter the sensitivity of insulin

Gender Eligibility for this Clinical Trial: Both

Minimum Age for this Clinical Trial: 13 Years

Maximum Age for this Clinical Trial: 25 Years

Are Healthy Volunteers Accepted for this Clinical Trial: No

Clinical Trial Investigator Information

  • Lead Sponsor
    • Cliniques universitaires Saint-Luc- Université Catholique de Louvain
  • Provider of Information About this Clinical Study
    • M.D. PhD V Beauloye, Cliniques universitaires Saint-Luc
  • Overall Official(s)
    • Veronique Beauloye, PhD, Principal Investigator, Cliniques universitaires Saint-Luc
  • Overall Contact(s)
    • Veronique VB Beauloye, PhD, +3227641370, Veronique.Beauloye@uclouvain.be

Source

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The URL of this page is:
http://clinicaltrialsfeeds.org/clinical-trials/show/NCT00716222