Official Title: “Study of the Kinetics of Uremic Toxins in the ICU Patients With Acute Renal Failure, in Order to Optimize the Dialysis Dose: Patients With Lactate Acidosis”

Study of the kinetics of uremic toxins in the ICU patients with acute renal failure, in order to optimize the dialysis dose: patients with lactate acidosis. The sampling of blood and dialysate will be done during dialysis with different durations (4, 6 and 8 h)

Study Type: Interventional

Study Design: Treatment, Randomized, Open Label, Active Control, Crossover Assignment, Efficacy Study

Study Primary Completion Date: December 2009

Intervention(s) in this Clinical Trial

• Procedure: Dialysis during 4 hours
  • Blood and dialysate sampling
• Procedure: Dialysis during 6 hours
  • Blood and dialysate sampling
• Procedure: Dialysis during 8 hours
  • Blood and dialysate sampling

Arms, Groups and Cohorts in this Clinical Trial

• Experimental: 1
  • Dialysis during 4 hours
• Experimental: 2
  • Dialysis during 6 hours
• Experimental: 3
  • Dialysis during 8 hours

Primary Measures

• Toxin removal
  • Time Frame: During dialysis
    Safety Issue?: No

Inclusion Criteria:

• Includes ICU patients with lactate acidosis with acute renal failure

Exclusion Criteria:

Gender Eligibility for this Clinical Trial: Both

Minimum Age for this Clinical Trial: 18 Years

Maximum Age for this Clinical Trial: N/A

Are Healthy Volunteers Accepted for this Clinical Trial?: No

Lead Sponsor: University Hospital, Ghent

Overall Clinical Trial Officials and Contacts

Raymond Vanholder, MD, PhD Principal Investigator University Hospital, Ghent  

Overall Contact: Sunny Eloot, PhD  Sunny.eloot@ugent.be

Information obtained from ClinicalTrials.gov on July 02, 2009

Link to the current ClinicalTrials.gov record. http://clinicaltrials.gov/show/NCT00752453

Study ID Number: 2008/375

ClinicalTrials.gov Identifier: NCT00752453

Health Authority: Belgium: Institutional Review Board

Website of the University Hospital Ghent