Prevalence of Coronary Artery Disease in the Siblings of Premature Coronary Heart Disease

Brief Summary

Official Title: “Assessment of Occult CAD: Premature CAD Sibling Study (PreCASS)”

The aim of this prospective study is to investigate the prevalence of coronary artery disease using computed tomography with family history of premature coronary heart disease

  • Study Type: Observational
  • Study Design: Observational Model: Cohort, Time Perspective: Prospective
  • Study Primary Completion Date: September 2012

Outcome Measures for this Clinical Trial

Primary Measures

  • evaluation of prevalence to coronary artery disease using CT
    • Time Frame: within 2 weeks from CT scanning
      Safety Issue?: No

Criteria for Participation in this Clinical Trial

Inclusion Criteria

  • within 1 year
  • the siblings of premature coronary heart disease (male<55years old, female<65yeasrs old: Framingham Heart Study) patients admitted relevant hospital

Exclusion Criteria

  • Documented coronary heart disease
  • experienced adverse events with relevant treatment
  • contraindicated with beta-blockers
  • Any woman of childbearing potential who is pregnant, seeking to become pregnant or suspects

Gender Eligibility for this Clinical Trial: Both

Minimum Age for this Clinical Trial: 18 Years

Maximum Age for this Clinical Trial: N/A

Are Healthy Volunteers Accepted for this Clinical Trial: No

Clinical Trial Investigator Information

  • Lead Sponsor
    • Yonsei University
  • Collaborator
    • Korean Society of Lipidology and Atherosclerosis
  • Provider of Information About this Clinical Study
    • Principal Investigator: Hyuk-Jae Chang, Yonsei University – Yonsei University
  • Overall Official(s)
    • Hyuk-Jae Chang, MD, PhD, Principal Investigator, Cardiology Division, Severance Cardiovascular Hospital, Yonsei University College of Medicine
  • Overall Contact(s)
    • Hyuk-Jae Chang, MD, PhD, 82-2-2228-8461,

Citations Reporting on Results

Arad Y, Spadaro LA, Goodman K, Newstein D, Guerci AD. Prediction of coronary events with electron beam computed tomography. J Am Coll Cardiol. 2000 Oct;36(4):1253-60.


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